Uncubed
           

Protein Engineer

Ginkgo Bioworks, Boston, MA

THE ORGANISM COMPANY


Our mission is to make biology easier to engineer.  Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more.  Our bioengineers make use of an in-house automated foundry for designing and building new organisms.  Today, our foundry is developing over 40 different organisms to make different products across multiple industries.

Key to the design of organisms for the production of cultured ingredients are the biosynthetic enzymes that make these natural products. We are seeking protein engineers interested in tackling the formidable challenge of developing our parts set for biosynthesis across microbial metabolism. As you develop this enzyme toolkit, you'll be tackling the full gamut of technical challenges: expression, solubility, localization, activity, substrate specificity, product profile, and more. As such, you'll need to bring the complete repertoire of solutions to bear on these problems, from synthetic metagenomics to directed evolution to rational protein engineering and more.

Responsibilities

  • Functional expression of enzyme families and classes
  • Apply rational protein engineering, directed evolution, synthetic metagenomics, and other approaches for enzyme redesign with the goal of improving expression, solubility, activity, substrate specificity, and product profile

Requirements

  • PhD or equivalent
  • Deep experience in enzyme catalysis
  • Deep experience in functional enzyme expression in microbial hosts
  • Experience in protein engineering or directed evolution
  • Experience in natural products chemistry and/or secondary metabolism a plus
  • Experience with HTP assays a plus
To learn more about Ginkgo, check out some recent press:

We also feel it’s important to point out the obvious here – there’s a serious lack of diversity in our industry and it needs to change.  Our goal is to help drive that change.  We hope to continue to build a company whose culture promotes inclusion and embraces how rewarding it is to work with engineers from all walks of life.  Making biology easier to engineer is a tough nut to crack –  we can’t afford to leave any talent untapped.  

It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

About Ginkgo Bioworks

Ginkgo Bioworks is the organism company. We design custom microbes for customers across multiple markets. We build our foundries to scale the process of organism engineering using software and hardware automation. Organism engineers at Ginkgo learn from nature to develop new organisms that replace technology with biology.

Want to learn more about Ginkgo Bioworks? Visit Ginkgo Bioworks's website.