Uncubed
   

Mammalian Computational Biologist, Design Team

Ginkgo Bioworks, Boston, MA

THE ORGANISM COMPANY

Duration: Full-Time


Our mission is to make biology easier to engineer. Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms.

As a Mammalian Computational Biologist working on the Design Team, you’ll support Ginkgo's mammalian cell engineering programs by designing and analyzing high-throughput experiments using a variety of synthetic biology and genomic approaches. You’ll work to develop novel computational tools that expand Ginkgo's mammalian cell engineering toolbox. As part of the Design Team, you will partner with an interdisciplinary team of bench scientists, computational biologists, data scientists, and software engineers, to develop world-changing tools to engineer biology. 

The successful candidate will bring their deep knowledge of mammalian gene regulation and transcription to design, support, and analyze synthetic biology projects within the foundry. The candidate will bring knowledge and experience in modern synthetic biology techniques applied to higher eukaryotes. To be successful in this role, you will think big and execute systematically. You will draw on your fluency in molecular biology, mammalian cell engineering and NGS to design, analyze and interpret large scale screens. You will put your organizational and communication muscles to work every day as you work closely with teams across Ginkgo.

Please note: we recognize that not all candidates may meet the entire list of Desired Experience and Capabilities. We’re eager to train the right candidates for this role, and encourage those who meet at least two-thirds of the criteria to apply. 

Notes on applying:
We look forward to hearing from you. Please send us the following:
* A cover letter describing a little about yourself, your prior work, your career goals, and what makes you interested in joining our team.
* A résumé or curriculum vitae.
* A sample of your code. A GitHub profile, if you have one, is preferred. Otherwise, attached files are okay.

Responsibilities

  • Integrate internal and external data to advance mammalian cell engineering projects and associated computational biology tools
  • Troubleshoot moderate- to high-complexity technical problems, proposing biological design solutions in the dry lab, and maintaining familiarity with protocols (e.g. cell culture, diagnostic/QC, assay design, and execution) in the wet lab
  • Support Ginkgo’s organism engineering teams with your expertise in mammalian synthetic biology, designing megabases of DNA for each project
  • Collaborate with stakeholders across Ginkgo to create the next generation of synthetic biology tools (e.g. algorithms, data structures, predictive models, software pipelines, and/or experimental approaches) that yield step changes in our ability to engineer mammalian cell lines
  • Maintain high-quality documentation of your work and discoveries, creating written reports, technical presentations, electronic lab notebooks, internal database records, code comments, and software documentation

Desired Experience and Capabilities

  • PhD (or equivalent experience) in mammalian genetics, genomics, immunology, systems biology, biochemistry, computational biology, quantitative biology, or other relevant field. Interdisciplinary work is strongly preferred
  • 2+ years of professional experience (grad school counts) working with mammalian genome engineering tools, such as CRISPR/Cas systems, recombinases, and viral vectors
  • Experience with pooled screening approaches using CRISPR/Cas systems, dCas constructs, or synthetic biology techniques
  • Proficiency with at least one software programming language (Python preferred). Knowledge of best practices for collaborative software development (version control systems, test-driven development, and good documentation habits). Familiarity with cloud services (e.g. AWS) is preferred
  • First-hand technical experience in at least two of the following areas: synthetic biology, bioinformatics, sequence analysis, genomics, NGS analysis, immunology, probabilistic modeling, machine learning, and quantitative modeling of biological systems
  • Demonstrated ability to meet the demands of multiple concurrent projects
  • Strong curiosity about (and comfort working in) areas of biology previously unknown to you and, at times, your peers
To learn more about Ginkgo, check out some recent press:

We also feel that it’s important to point out the obvious here – there’s a serious lack of diversity in our industry, and that needs to change. Our goal is to help drive that change. Ginkgo is deeply committed to diversity, equity, and inclusion in all of its practices, especially when it comes to growing our team. Our culture promotes inclusion and embraces how rewarding it is to work with people from all walks of life.  

We’re developing a powerful biological engineering platform, so we must remain mindful of the many ways our technology can – and will – impact people around the world. We care about how our platform is used, and having a diverse team to build it gives us the best chance that it’s something we’ll be proud of as it continues to grow. Therefore, it’s critical that we incorporate the diverse voices and visions of all those who play a role in the future of biology.

It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

About Ginkgo Bioworks

Ginkgo Bioworks is the organism company. We design custom microbes for customers across multiple markets. We build our foundries to scale the process of organism engineering using software and hardware automation. Organism engineers at Ginkgo learn from nature to develop new organisms that replace technology with biology.

Want to learn more about Ginkgo Bioworks? Visit Ginkgo Bioworks's website.